與DNA-PK類似，ATM也是屬于PI3K激酶活性的蛋白~
Ataxia telangiectasia-mutated protein kinase (ATM) : 毛細血管擴張性共濟失調(diào)突變蛋白激酶
是一種PI3K樣的絲氨酸/蘇氨酸激酶，包含有PI3K結構域和Rad3結構域，參與了激活細胞周期關卡，控制端粒長度和應答DNA損傷等生物學過程。 DNA雙鏈斷裂會導致ATM蛋白激酶的激活?？梢员籄TM磷酸化的下游靶點包括p53和NBS1蛋白以及組蛋白變體H2AX。通過這種方式， ATM可以影響細胞周期的過程和DSB修復以及細胞凋亡。
taxia telangiectasia mutated (ATM), a serine/threonine protein kinase , is a member of PI3K family proteins. ATM is activated by DNA damage. ATM can phosphorylate many kinase such as p53 and CHK2, resulting in apoptosis and cell cycle arrrest. ATM can be retrieved from nuclear extracts by DNA oligonucleotides or by DNA finity chromatography becasue ATM can bind to DNA. The checkpoint clamp proteins may play the role in modulating the signal (via its processing) or the transmission of the signal. The active PIKK then activates and/or recruits the checkpoint kinases of the Chk1/Chk2 families, which act as effector kinases of the DNA damage pathways. DNA damage can be detected (either directly or after processing) by ATM. In vertebrates, different DNA damage signals elicit either a branch composed of the ATM-Chk2 axis.
ATM 抑制劑
| 目錄號 |
產(chǎn)品名稱 |
產(chǎn)品描述 |
| S1092 |
KU-55933 |
KU-55933是有效的特定ATM抑制劑，IC50為13 nM，Ki值為2.2 nM。 |
| S1570 |
KU-60019 |
KU-60019 is a specific improved ATM kinase inhibitor. |
| S2245 |
CP-466722 |
CP-466722 is rapidly reversible potential ATM kinase inhibitor. |